PATTERN MATCHING IN MODELS

The goal of this paper is to investigate how such a pattern matching could be performed on models,including the definition of the input language as well as the elaboration of efficient matchingalgorithms. Design patterns can be considered reusable micro-architectures that contribute to anoverall system architecture. Frameworks are also closely related to design patterns. Componentsoffer the possibility to radically change the behaviors and services offered by an application bysubstitution or addition of new components, even a long time after deployment. Software testing isanother aspect of reliable development. Testing activities mainly consist in ensuring that a systemimplementation conforms to its specifications

Aspecte definitorii privind sistemele de management al calitatii in intreprinderile mici si mijlocii

In mod traditional, standardele internationale din domeniul calitatii, nu favorizau implementarea sistemelor de management al calitatii in intreprinderile de dimensiuni reduse, date fiind dificultatile cu care se confruntau aceste organizatii in realizarea unui numar ridicat de documente, precum si in gestionarea cheltuielilor de implementare si certificare. In prezent, literatura de specialitate recunoaste necesitatea de dezvoltare a activitatii intreprinderilor mici si mijlocii plecand de la principiile managementului calitatii. Scopul prezentei lucrari este de a surprinde modul specific de aplicare a sistemelor de management al calitatii in IMM-uri, prin descrierea particularitatilor referitoare la rolul conducerii, asigurarea resurselor, realizarea si evaluarea produselor si monitorizarea proceselor.managementul calitatii, intreprinderi mici si mijlocii, standarde internationale, politica calitatii, quality management, small and medium enterprises, international standards, quality policy

Hind Right Approach Pancreaticoduodenectomy: From Skill to Indications

Background. Pancreaticoduodenectomy is the potentially curative treatment for malignant and several benign conditions of the pancreatic head and periampullary region. While performing pancreaticoduodenectomy, early neck division may be impossible or inadequate in case of hepatic artery anatomic variants, suspected involvement of the superior mesenteric vessels, intraductal papillary mucinous neoplasm, and pancreatic head bleeding pseudoaneurysm. Our work aims to highlight a particular hind right approach pancreaticoduodenectomy in selected indications and assess the preliminary results. Methods. We describe our early hind right approach to the retropancreatic vasculature during pancreaticoduodenectomy by mesopancreas dissection before any pancreatic or digestive transection. Results. We used this approach in 52 patients. Thirty-two had hepatic artery anatomic variant and 2 had bleeding pancreatic head pseudoaneurysm. The hepatic artery variant was preserved in all cases out of 2 in which arterial reconstruction was performed. In nine patients with intraductal papillary mucinous neoplasms the pancreaticoduodenectomy was extended to the body in 6 and totalized in 3 patients. Seven patients with adenocarcinoma involving the portomesenteric axis required venous resection and reconstruction. Conclusions. Early hind right approach is advocated in selected cases of pancreaticoduodenectomy to improve locoregional vascular control and determine, safely and early, whether there is mesopancreas involvement

Evaluation of New Morphometric Parameters of Neoangiogenesis in Human Colorectal Cancer Using Confocal Laser Endomicroscopy (CLE) and Targeted Panendothelial Markers

The tumor microcirculation is characterized by an abnormal vascular network with dilated, tortuous and saccular vessels. Therefore, imaging the tumor vasculature and determining its morphometric characteristics represent a critical goal for optimizing the cancer treatment that targets the blood vessels (i.e. antiangiogenesis therapy). The aim of this study was to evaluate new vascular morphometric parameters in colorectal cancer, difficult to achieve through conventional immunohistochemistry, by using the confocal laser endomicroscopy method. Fresh biopsies from tumor and normal tissue were collected during colonoscopy from five patients with T3 colorectal carcinoma without metastasis and were marked with fluorescently labeled anti-CD31 antibodies. A series of optical slices spanning 250 µm inside the tissue were immediately collected for each sample using a confocal laser endomicroscope. All measurements were expressed as the mean ± standard error. The mean diameter of tumor vessels was significantly larger than the normal vessels (9.46±0.4 µm vs. 7.60±0.3 µm, p = 0.0166). The vessel density was also significantly higher in the cancer vs. normal tissue samples (5541.05±262.81 vs. 3755.79±194.96 vessels/mm3, p = 0.0006). These results were confirmed by immunohistochemistry. In addition, the tortuosity index and vessel lengths were not significantly different (1.05±0.016 and 28.30±3.27 µm in normal tissue, vs. 1.07±0.008 and 26.49±3.18 µm in tumor tissue respectively, p = 0.5357 and p = 0.7033). The daughter/mother ratio (ratio of the sum of the squares of daughter vessel radii over the square of the mother vessel radius) was 1.15±0.09 in normal tissue, and 1.21±0.08 in tumor tissue (p = 0.6531). The confocal laser endomicroscopy is feasible for measuring more vascular parameters from fresh tumor biopsies than conventional immunohistochemistry alone. Provided new contrast agents will be clinically available, future in vivo use of CLE could lead to identification of novel biomarkers based on the morphometric characteristics of tumor vasculature

Therapeutic Considerations Related to Finasteride Administration in Male Androgenic Alopecia and Benign Prostatic Hyperplasia

Finasteride has been used extensively until now as a relative efficient therapeutic option for male androgenic alopecia and benign prostatic hyperplasia. Unfortunately, over time several concerns appeared regarding the frequency and magnitude of adverse effects, which in some cases have been even irreversible. Herein we review the recent literature on this topic, trying to clarify the current safety profile of Finasteride for these two therapeutic indications. We concluded that Finasteride could be retained as a therapeutic approach for male androgenic alopecia, based on two important reasons. First, a synergistic action between a partial inhibitor of 5α-reductase (Finasteride) and another compound (like Minoxidil) are preferable to a complete suppression of 5α-reductase (see Dutasteride), in order to preserve the important physiological roles of dihydrotestosterone. Second, Finasteride side effects can currently be addressed in part prior to the onset of the therapy, by using information about the patient such as hand preference and sexual orientation to predict the risk of adverse effects

Selective Symbolic Execution

Symbolic execution is a powerful technique for analyzing program behavior, finding bugs, and generating tests, but suffers from severely limited scalability: the largest programs that can be symbolically executed today are on the order of thousands of lines of code. To ensure feasibility of symbolic execution, even small programs must curtail their interactions with libraries, the operating system, and hardware devices. This paper introduces selective symbolic execution, a technique for creating the illusion of full-system symbolic execution, while symbolically running only the code that is of interest to the developer. We describe a prototype that can symbolically execute arbitrary portions of a full system, including applications, libraries, operating system, and device drivers. It seamlessly transitions back and forth between symbolic and concrete execution, while transparently converting system state from symbolic to concrete and back. Our technique makes symbolic execution practical for large software that runs in real environments, without requiring explicit modeling of these environments

Preliminary results concerning maize leaf weevil (Tanymecus dilaticollis Gyll) control, in commercial farm conditions, from South-East of the Romania

Preliminary results concerning maize leaf weevil (Tanymecus dilaticollis Gyll) control, in commercial farm conditions, from South-East of the Romani